Molybdenum Disulfide (MoS2) is the leading dry film lubricant (DFL) for space applications due to its superior tribological performance in space conditions. However, MoS2 DFLs are sensitive to the operating environment. In this study, we characterized sputter-deposited MoS2-based DFLs, either undoped or with Ni, Ti, or Sb2O3 + Au dopants. The DFLs were tribotested in dry nitrogen and air conditions at room temperature, as well as in dry nitrogen at 0 °C. Unidirectional sliding tests were run until coating failure to measure friction coefficient and wear life. All four DFLs had lower friction and longer wear life in dry nitrogen than in air and some performed slightly better at room temperature than at 0 °C. Ni doping had a minimal effect on friction and wear life in any of the testing conditions but Ti or Sb2O3 + Au dopants led to improved performance in some conditions. Notably, Ti-doped coatings exhibited the least sensitivity to environment and temperature, and the Sb2O3 + Au-doped coatings had the best wear life of the DFLs in all testing conditions. Finally, short duration tribotests were performed and the wear tracks were analyzed using scanning electron microscopy to identify possible mechanisms underlying observed trends. Graphical Abstract