Biofouling on implantable medical devices (IMDs) is a significant clinical challenge due to associated infections, treatment resistance, and ultimate device failure. Coating the surface of IMDs with materials that can reduce/prevent bacterial attachment remains a leading approach in infection prevention. Slippery lubricant-infused porous surfaces (SLIPS) have been shown to be promising in resisting biofouling; however, lack of surface stability (marked by lubricant depletion) and material's biocompatibility are the main hurdles toward its practicality. Here, by exploiting encapsulation properties of supramolecular structures through host-guest chemistry, namely, cyclodextrins metal–organic frameworks, lubricant chains are entrapped inside their cavities – producing completely biocompatible SLIPS with excellent durability. This molecular-woven network with reticular architecture and unique slippery properties is further held within polydimethylsiloxane matrix and coated on 3D printed oesophagus stents as proof-of-concept demonstration. The coatings maintained slipperiness under harsh water droplet shedding for 40 h, continuous water flow for >90 h (350 L/h), and showed excellent resistance against protein (bovine serum albumin), bacterial (S. aureus and E. Coli), and cell (L929 fibroblast) attachment. This SLIPS is soft (Young's modulus of 18.7 ± 1.6 MPa), which may offer advantage in terms of its potential use on IMDs and in applications such as food packaging.