Refractory high-entropy alloys (RHEAs) are promising next-generation nuclear cladding materials due to their high-temperature stability and mechanical strength. This study developed a low-activation RHEA WCrTaVTi 0.5 that features a BCC matrix with dispersed Laves phases and β-Ti-based solid solutions. Oxidation tests at 600 °C revealed a protective composite oxide layer, demonstrating exceptional oxidation resistance. Tribological evaluations showed superior wear performance compared to Zr-4 alloy, attributed to high hardness and compact tribo-oxide layers. The WCrTaVTi 0.5 alloy exhibited wear rates of 6.65 (RT) and 1.19 × 10 −5 mm 3/N·m (600 °C), significantly lower than Zr-4104.12 and 84.70 × 10 −5 mm 3/N·m. Notably, it achieved an ultralow wear rate of 0.21 × 10 −5 mm 3/N·m at 200 °C. These results highlight the alloy's potential for nuclear applications.