In this study, Titanium Nitride (TiN), Chromium Nitride (CrN), and Titanium Diboride(TiB2) coatings were deposited on a Ti6Al4V alloy substrate, by using the RF magnetron sputter deposition technique. An examination was carried out to meticulously compare the phase composition, microstructure, and mechanical and tribological properties of the three coating types. XRD, Optical 3D-profilometer, FESEM, EDAX, WDXRF, Raman spectroscopy, nanoindentation, and scratch test techniques were employed for the comprehensive characterization of coating properties, including phase composition, microstructure, and mechanical behavior. A universal tribometer was used to measure the friction and wear coefficients under different sliding distances. The nanoindentation test outcomes revealed that the CrN coating exhibited elastic modulus (E) and hardness (H) values of approximately 172.62 ± 8.6   GPa and 12.57 ± 0.7   GPa, respectively. These values were higher compared to those of the TiN and TiB2 coatings. According to the adhesive strength analysis in the scratch test, the critical load value for CrN was 592.1 mN, significantly outperforming the critical loads for both TiN and TiB2 coatings. Among the three coatings, the CrN coating demonstrated superior tribological performance, displaying the lowest friction coefficients and wear coefficients across various sliding distances against a SiC ball. Additionally, an analysis of the wear mechanisms for all three types of coatings was conducted. The analysis indicates that the use of CrN coating on a Ti6Al4V alloy would result in improved service life and better endurance in machine components, cutting tools, and aerospace applications.